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Increased expression of DAF-16, the ortholog of human FoxO proteins in the worm Caenorhabditis elegans , due to a mutation of the insulin/IGF-1 receptor daf-2 has been found to significantly increase the worm's lifespan [2, 3]

However, these peptides behave very differently due to structural modifications that affect their half-life, receptor sensitivity, and tissue selectivity

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